CHICAGO, (Reuters) – Using skin cells taken from children with a rare heart defect, U.S. researchers have created beating heart cells in the lab with the same heart defect, allowing researchers to test new drugs in human cells instead of mice.
While most heart drugs had no effect on the cells, a cancer drug being studied by Cyclacel Pharmaceuticals Inc appears to help, the team led by Ricardo Dolmetsch of Stanford University reported on Wednesday in the journal Nature.
The study is among the first to use powerful new technology to create human models of disease by reprogramming ordinary