Developing nations could face flu drug shortages

GENEVA (Reuters) – Developing countries may struggle to gain access to the antiviral drugs they need to combat a fast-spreading outbreak of swine flu.

“It is going to become a problem,” said Sangeeta Shashikant of the Third World Network, which campaigns for better drug access for the poor.

She said “advance purchase agreements” and other deals securing medicines for wealthy governments could drain the global supply chain of effective medicines.

The antiviral drugs Tamiflu made by Swiss drugmaker Roche Holding AG and Relenza, made by GlaxoSmithKline , have been shown to be effective against the swine flu strain that has infected people in Mexico, the United States, Canada, Spain and Britain. Up to 149 people have died in Mexico.

But there are not likely to be enough doses to treat the whole world in a pandemic, and production is limited.

“Many countries have stockpiled antivirals, although how to deliver them within a maximum of 48 hours remains a huge challenge,” the London School of Hygiene and Tropical Medicine said in a statement.

“Preparedness levels in middle income and lower income countries remain low. Therefore it is likely that this flu outbreak will also be a test for global solidarity.”

UN Secretary-General Ban Ki-moon used the same expression in his appeal for assistance for states vulnerable to the health crisis who may need drugs, diagnostic tools and other help. “If we are indeed facing a pandemic, we need to demonstrate global solidarity,” he said in a statement.

“Poorer nations are especially vulnerable. They have been hit hard by other crises this year: food, energy, the global economy, climate change. We must ensure that they are not also hit disproportionately hard by a potential health crisis.”

Mike Palmedo, research coordinator at American University’s programme on information justice and intellectual property, said the international community should ensure drugs reach those who need them in order to avoid needless deaths.

“I suspect that in the event of an epidemic, many countries would find their supplies inadequate,” he said, suggesting that increased generic production could help ease shortfalls.

“Whatever the amount of drugs currently available, more generic competition would drive prices down further, making access available to more countries.”

India’s Cipla began to manufacture generic oseltamivir, or Tamiflu, in 2006, and Ranbaxy and Hetero also make the drug in India. Shanghai Pharmaceuticals and HEC make it in China, according to Palmedo.