Ricky Ponting (209) and Michael Clarke (166) shared 352, the second-highest fourth-wicket partnership in Australian Test history as they declared on 519-8.
Pakistan, who trail 2-0 in the series, self-destructed with two run-outs.
Salman Butt (34 not out) was involved in the dismissals of both captain Mohammad Yousuf (7) and Umar Akmal (8).
Yousuf’s dismissal came after he played a superb off-drive off Doug Bollinger and, having run two, called for a legitimate third run.
However, Butt refused to run at the non-striker’s end and his skipper was left stranded.
A few overs later, Butt again refused to run, leaving teenager Umar heading back to the pavilion.
The tourists, who need another 226 runs to avoid the follow-on, were already in trouble after Peter Siddle had claimed the wickets of Imran Farhat (38) and Manzoor (0).
Pakistan captain Yousuf later branded team-mate Butt as “selfish”.
“We are not playing for self, we are playing for country,” said Yousuf. “I am 35 years old, he is 25 years old, why not take three runs?”
